Our Scientific Focus
Our research program aims to obtain rigorous mechanistic insights into the structure, dynamics, and function of important classes of membrane proteins and prominent drug targets, including G protein-coupled receptors (GPCRs), transporters, channels, and beta3 integrins.
The strength of our research relies on the integration of state-of-the-art computational methodologies with collaborative experimental approaches to provide valuable mechanistic interpretations at the molecular level of the ligand-induced transmission of the signal to the inner side of the cell membrane.
Rigorous Research Methods
We utilize a variety of tools and techniques, including molecular modeling, bioinformatics, cheminformatics, molecular dynamics simulations, metadynamics, free-energy perturbations, artificial intelligence/machine learning.
Translational Relevance
While our research is driven by the exploration and improvement of computational methods to characterize generalizable mechanisms of molecular recognition and signal transduction, we are excited by the contributions that our computational and modeling efforts make to the experimental field through the generation of new testable hypotheses to support the discovery of improved therapies.
Dedicated to Discovery
Our team is committed to advancing the field of computational structural biology and drug discovery.
Partner with Us
We welcome collaborations and partnerships with individuals and organizations who share our passion for cutting-edge research and advancements in the field of membrane proteins and drug discovery.
Photo Gallery
The Filizola Lab Through the Years.