About Us

The Filizola Laboratory uses a variety of computational structural biology tools, ranging from molecular modeling, bioinformatics, chemoinformatics, simulation, and rational drug design approaches, to achieve a detailed mechanistic understanding of signal transduction processes triggered by molecular recognition in membrane protein complex systems such as G Protein-Coupled Receptors (GPCRs) and platelet integrin aIIbb3. The strength of our research relies on the integration of state-of-the-art computational methodologies with collaborative experimental approaches to provide valuable mechanistic interpretations at the molecular level of the ligand-induced transmission of the signal to the inner side of the cell membrane. While our research is driven by the exploration and improvement of computational methods to characterize generalizable mechanisms of molecular recognition and signal transduction, we are excited by the contributions that our computational and modeling efforts make to the experimental field through the generation of new testable hypotheses.

We belong to the Department of Structural and Chemical Biology of Icahn School of Medicine at Mount Sinai (New York, NY, USA), and are physically located on the 16th (room 16-20F; PI’s office) and 15th (suite 15-23; laboratory) floors of the Icahn Medical Institute (East Building; 1425 Madison Ave, New York, NY, 10029).